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The best method is to leave the nozzle attached ensuring it is fully screwed on to provide the best possible seal to the cartridge thread and then squeeze out a small 'Dag' of sealant from the tip of the nozzle and leave it to cure.

This effectively forms a plug and slows further curing of the sealant down through the nozzle. When you need to use it next just pull carefully on the hardened plug and it should pull out leaving the nozzle ready to extrude product. If it breaks off or the sealant has cured further down, unscrew the nozzle and clean it out with a piece of wire or small screwdriver, re-attach and you’re ready to go again.